Exosomal miR-21-5p derived from bone marrow mesenchymal stem cells promote osteosarcoma cell proliferation and invasion by targeting PIK3R1.

J Cell Mol Med · 2021 · PMC8642676 · PMID 34741385

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After treatment with the MSC‐derived exosomes (MSCs treated with miR‐21‐5p mimics), the expression levels of p‐Akt, p‐mTOR and p‐PI3K in OS cells all showed an increasing trend, whereas the expression of PIK3R1 sharply decreased ( p < 0.05).

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