Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice.

To determine whether inflammatory cytokines also declined, we measured the protein levels of iNOS and IBA1 in the hippocampus and found that upon LPS challenge they were significantly reduced in cKO mice, with a decreasing trend of GFAP levels compared with Dlg1 flox/flox mice (Fig. 5 A–D).

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