Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.

Nucleic Acids Res · 2021 · PMC8643693 · PMID 34850120

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highly significantno p-value reported

Oligonucleotides do not distribute uniformly in many tissues, specifically CNS, resulting in highly significant differences in degree of accumulation across brain regions ( 47 , 56 ).

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