Although the active form (∼75 KDa) demonstrated an increasing trend upon infection, the change was insignificant compared with mock brain lysates ( Fig. 1 , J). 3.2 Induction of TIMP-1 expression following MHV-A59 infection Tissue inhibitors of metalloproteinases or TIMPs are endogenous protein regulators of MMPs ( Murphy, 2011 ).
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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in murine β-coronavirus-induced neuroinflammation.
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