Flexible extension of the accelerated failure time model to account for nonlinear and time-dependent effects of covariates on the hazard.

40 In contrast, all simpler models (i)–(iii), that did not allow for TD effects, suggested constant-over-time effects of both factors were marginally nonsignificant ( Table 2 ) and under-estimated their long-term impact, relative to our TD time ratio estimates in Table A5.1.2 .

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