Olefin Metathesis in Continuous Flow Reactor Employing Polar Ruthenium Catalyst and Soluble Metal Scavenger for Instant Purification of Products of Pharmaceutical Interest.

Unfortunately, owing to the detrimental effect of these reaction media on the environment (dichloromethane and 1,2-dichloroethane belong to ICH class 1 and toluene to ICH class 2 solvents), 58 their use, especially in industrial processes, is restricted or even prohibited. Green chemistry is an increasing trend not only in chemical industry but also in academia. 59 − 62 Despite the environmental needs and the availability of many alternative solvents such as water, 63 ethyl acetate, 64 , 65 dimethyl carbonate, 66 , 67 2-MeTHF, 68 , 69 and 4-MeTHP, 61 , 70 the usage of green solvent for olefin metathesis is relatively scarce.

also in 63,971 other papers