Evaluation of the Utility of Amino Acid Citrulline as a Surrogate Metabolomic Biomarker for the Diagnosis of Celiac Disease.

Table 4 depicts the detailed comparison analysis of plasma citrulline levels with the presence and absence of HLA genotype Agreement between plasma citrulline and DBS filter paper citrulline assay Correlation between plasma and DBS filter paper citrulline levels was evaluated in 405 cases and the obtained correlation was statistically highly significant (Interclass Correlation Coefficient = .50, P < .001).

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We noted an inverse correlation between plasma citrulline and serum tTG-IgA levels and observed an increasing trend of plasma citrulline levels with decreasing trends of serum tTG-IgA levels at different Marsh grades.

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