Barely Significant
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Increased Leishmania infantum resistance to miltefosine and amphotericin B after treatment of a dog with miltefosine and allopurinol.

Parasit Vectors · 2021 · PMC8656069 · PMID 34886876

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an increasing trendno p-value reported
An increasing trend in the metacyclogenesis rate of the parasites was also observed as drug resistance increased.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.