Chimeric Investigations into the Diamide Binding Site on the Lepidopteran Ryanodine Receptor.

RF-PxRyR, when expressed in Sf9 cells, shows a highly significant reduction in CLR response relative to WT-PxRyR ( Figure 5 ) and suggests that the two amino acid alterations K4700R and Y4701F in tandem are responsible for mediating a majority of the RFCLM-PxRyR phenotype.

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