Factors Associated with Unfavourable Treatment Outcomes in Patients with Tuberculosis: A 16-Year Cohort Study (2005-2020), Republic of Karakalpakstan, Uzbekistan.

In Uzbekistan, the difference of treatment outcomes in districts is probably explained by a number of factors that include: (a) different rates of drug resistance; (b) the capacity of the district health systems to detect and treat cases early and follow them up, particularly in the continuation phase of treatment; (c) quality of primary health care services as a first point of screening of presumptive TB; (d) compliance with treatment guidelines (there was an increasing trend in using standardized regimens from 2% in 2012 to 44% in 2018 for the treatment of MDR TB patients [ 14 ]; and (e) patient characteristics such as migration and population mobility.

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