Piano-Stool Ruthenium(II) Complexes with Delayed Cytotoxic Activity: Origin of the Lag Time.

Second, as k 2 is clearly significantly higher than k 1 (as indicated by the 31 P{ 1 H} NMR experiments), once 2 Cl 2 iPr and 2 I 2 iPr are converted into their respective intermediates A , the subsequent cyclometalation reaction to yield 3 Cl iPr and 3 I iPr is immediate ( k 2 ≫ k 1 ), not allowing a determination of the value of k 2 under the experimental conditions applied in the present study.

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