An optimal growth law for RNA composition and its partial implementation through ribosomal and tRNA gene locations in bacterial genomes.

We indeed find statistically highly significant negative correlations between the predicted tRNA/ribosome gene dosage ratio (Eq ( 21 )) and μ max ( Fig 3D ; slowly growing species: ρ = −0.44, P = 2.8×10 −7 , P ic = 6.0×10 −4 ; fast-growing species: ρ = −0.49, P = 4.3×10 −4 , P ic = 0.037) (see Text C in S1 File for the treatment of tRNA genes; these calculations assume a constant DNA replication rate k rep = 1000 s -1 across species, see Text A in S1 File for species-specific replication rate k rep ).

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