Genomic profiles and their associations with TMB, PD-L1 expression, and immune cell infiltration landscapes in synchronous multiple primary lung cancers.

LRP1B-mutant tumors had a significantly higher percentage of positive PD-L1 TPS vs those with wild-type LRP1B (28.6% vs 2.9%; p=0.001), and TP53-mutant tumors presented with a positive trend (12.5% vs 3.1%; p=0.079) ( figure 4A ).

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Squamous cell carcinoma was more common in past studies, 4 20 21 but adenocarcinoma and GGO have become more common in recent studies, 22 23 in accordance with an increasing trend of lung cancer in non-smoking women. 24 Mutational profile of MPLCs We detected 833 somatic variations in 248 lesions after performing 1021-gene panel NGS on 255 lesion samples from 112 patients with MPLC ( figure 2A ).

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