Development of an Innovative Berberine Food-Grade Formulation with an Ameliorated Absorption: In Vitro Evidence Confirmed by Healthy Human Volunteers Pharmacokinetic Study.

Evid Based Complement Alternat Med · 2021 · PMC8665891 · PMID 34904017

Europe PMC DOI

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highly significantno p-value reported

Most importantly, when BBR-PP was orally administered to healthy volunteers, the advantages in terms of solubility and bioaccessibility seen in vitro are reflected in a highly significant increase in plasma berberine concentrations versus the unformulated berberine.

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