Changes in gene-gene interactions associated with cancer onset and progression are largely independent of changes in gene expression.

The observation that increased tissue specificity is associated with cancer progression may be significant in view of previously reported divergence in mutational landscape of cancer evolution, from an initial set of common mutations in driver genes to rare mutations in a broad spectrum of genes at late stages of cancer development ( Gerstung et al., 2020 ).

also in 13,097 other papers