Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review.

Although the study was not designed to obtain relevant observations in functional endpoints, a positive trend in some clinical measurements such as ALS Functional Rating Scale (ALSFRS-R), slow vital capacity (SVC), and manual muscle testing (MMT) was observed with the highest dose (Meininger et al., 2014 ).

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