Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder.

Transl Psychiatry · 2021 · PMC8668990 · PMID 34903712

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

a trend toward significanceP = 0.07so close (0.05 < p ≤ 0.1)

Confirmation analyses In the confirmation analysis using the DMN regions from the Power 264 atlas as the 47 ROIs, the interaction effect showed a trend toward significance in the within-subsystem rsFC of the core subsystem ( P = 0.07, FDR corrected) and the between-subsystem rsFC between the core and dMPFC subsystems ( P = 0.06, FDR corrected).

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a trend towards significanceP = 0.07so close (0.05 < p ≤ 0.1)

Similar to the main findings, an interaction effect between group and time in the within-subsystem rsFC of the core subsystem ( P < 0.05, uncorrected) and a trend towards significance in the interaction effect of the rsFC between the core subsystem and the dMPFC subsystem ( P = 0.07, uncorrected) were observed.

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