Medication Related Osteonecrosis of the Jaw: 2021 Position Statement of the Korean Society for Bone and Mineral Research and the Korean Association of Oral and Maxillofacial Surgeons.

MRONJ was not reported in the first 3-year randomized controlled trial (RCT) with denosumab in osteoporosis patients,[ 56 ] and several cases were reported in subsequent 10-year extension studies.[ 57 ] 2) Demographic and lifestyle factor Lifestyle and demographic factors, such as increased age, being female, smoking, and obesity, have been reported to be associated with an increased risk of MRONJ.[ 58 ] MRONJ shows an increasing trend in patients of old age.

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