highly significantp ≤0.01
After IP administration, there were highly significant increases in both measured C max values (about 2.7-fold) and AUC 0–∞ (about 2.4-fold) for all tested LNC formulations compared to the TSIIA suspension ( p ≤0.01), indicating a marked increase in the amount of TSIIA reaching the systemic circulation and enhanced systemic bioavailability.