Circadian and chemotherapy-related changes in urinary modified nucleosides excretion in patients with metastatic colorectal cancer.

Having an increasing or a decreasing trend (slope of regression line with p-value ≤ 0.05) in these urinary nucleosides after chemotherapy was associated with a > 50% delayed increase in plasma CEA (Fisher's exact test p-value = 0.0275) and a poor survival (two-sample t-test, p-value = 0.0054) (Table 3 ).

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