Barely Significant
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A case control study of occupation and cardiovascular disease risk in Japanese men and women.

Sci Rep · 2021 · PMC8671491 · PMID 34907236

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an increasing trendno p-value reported
Female food and drink preparatory workers also exhibited an increasing trend in the risk of all three subtypes of stroke, although these associations were not statistically significant.

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a decreasing trendno p-value reported
Introduction The incidence of cardiovascular disease (CVD), including stroke and coronary heart disease (CHD), has exhibited a decreasing trend in Japan since the late twentieth century 1 .

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.