IL-4i1 Regulation of Immune Protection During Mycobacterium tuberculosis Infection.

IL-4i1 deficiency in BMDMs resulted in a decreasing trend of intracellular mycobacterial growth at 1 and 3 days after infection with virulent H37Rv Mtb strain ( Figure 1B ).

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We observed an increasing trend of phenylalanine levels intracellularly in BMDMs during Mtb infection, and these levels were significantly increased in IL-4i1 −/− BMDMs compared with WT BMDMs 1 day after infection ( Supplementary Figure 1 E ).

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