Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging.

RT‐qPCR analysis of the liver (Figure 6b ) and lung (Figure 6c ) tissues showed that multiple senescence markers and SASP genes were either significantly reduced or were trending toward significance compared to vehicle treated mice, including p21 Cip1 , Tnfα , and Mcp1 .

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