highly significantP < 0.0001
The least square (LS) mean differences compared with placebo in SPID6 values for the 62.5, 125, 250-mg, and combined DFN-15 groups were −756.6, −1120.7, −1355.1, and −1076.9, respectively, which were statistically highly significant for all comparisons ( P < 0.0001, ANCOVA model).