Testing for potential confounders There were significant correlations between the overall trial size (total sample size at randomization) and a number of other variables of interest: These included overall PRECIS-2 scores, driven by highly significant correlations with the domains “setting,” “organization,” and “analysis.” Larger trials were also less likely to show differential attrition, irrespective of in which group most drop-outs occurred (treatment vs control group) (Table 4 ).
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