Reduction in C-Peptide Levels and Influence on Pharmacokinetics and Pharmacodynamics of Insulin Preparations: How to Conduct a High-Quality Euglycemic Clamp Study.

The AUC 0–24 h in groups A, B, and C were 9.7 ± 2.2, 11.0 ± 2.9, and 11.9 ± 2.1 ng/ml × min, respectively, which indicated an increasing trend in the three groups ( P trend = 0.041).

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There was a significant difference in average glucose levels across the three groups ( p = 0.000): Group C had lower mean glucose than groups A and B, revealing a decreasing trend in all groups (P trend = 0.000).

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