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Optimal control methods for drug delivery in cancerous tumour by anti-angiogenic therapy and chemotherapy.

IET Syst Biol · 2021 · PMC8675840 · PMID 33491873

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an increasing trendno p-value reported
In steepest descent method, ECs has three different behaviours with the passage of time: First, it has an increasing trend, which is because of the existence of CCs in body due to angiogenesis.

also in 63,971 other papers

a decreasing trendno p-value reported
Second, a decreasing trend which is the effect of AA against CCs in body.

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.