Transcriptomic Changes Highly Similar to Alzheimer's Disease Are Observed in a Subpopulation of Individuals During Normal Brain Aging.

Front Aging Neurosci · 2021 · PMC8675870 · PMID 34924992

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highly significantno p-value reported

This is highly significant, as Rooij2019 down-regulated genes (1,622 genes) overlap with another AD signature, Annese2018 down-regulated genes (1,183 genes) by 614 genes, which is comparable to the overlap we see with aging subgroup DEGs.

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