an increasing trendP = .002
HADS-A score and anxiety rate at different time points HADS-A score was 6.9 ± 3.1, 7.3 ± 3.1, 7.7 ± 3.3, and 8.0 ± 3.5 at M0, M12, M24, and M36, respectively, which exhibited an increasing trend ( P = .002) (Table S1, Supplemental Digital Content, http://links.lww.com/MD/G520 ) (Fig. 1 A).