NLRP1 inflammasome involves in learning and memory impairments and neuronal damages during aging process in mice.

In the orientation navigation experiment, compared with the first day (d1), the escape latency in 6 M, 16 M and 20 M group had a decreasing trend and significantly decreased on d4 in 6 M group (Fig. 2 A; F(3,44) = 4.746, P < 0.01), on d3 in 16 M group (Fig. 2 A; F(3,44) = 4.556, P < 0.05), and on d4 in 20 M group (Fig. 2 A; F(3,44) = 3.885, P < 0.05).

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