DNA methylation variation along the cancer epigenome and the identification of novel epigenetic driver events.

We observed a highly significant difference in the mean correlation values ( P -value < 2.2e-16, lower-tailed Wilcoxon rank sum test), with a median correlation value of -0.15 for the differentially methylated promoters detected by MethylDriver, more than twice as strong as the average association for all promoters ( Supplementary Figure S4 ).

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