The nedd-8 activating enzyme gene underlies genetic resistance to infectious pancreatic necrosis virus in Atlantic salmon.

Genomics · 2021 · PMC8682971 · PMID 34547402

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highly significantno p-value reported

The role of nae 1 in IPN resistance was further assessed via CRISPR-Cas9 knockout of the nae 1 gene and chemical inhibition of the nae1 protein activity in Atlantic salmon cell lines, both of which resulted in highly significant reduction in productive IPNV replication.

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