Remarkably, we observed a highly significant overlap between cassette exons regulated by NEK2 and those differentially expressed between epithelial and mesenchymal BC cells and tissues identified in a previous study [ 49 ] (Fig. 6 F, Additional File 4 : Supplemental Table 8).
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The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells.
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