SCEPTRE improves calibration and sensitivity in single-cell CRISPR screen analysis.

Genome Biol · 2021 · PMC8686614 · PMID 34930414

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closest p

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highly significantno p-value reported

limited the accuracy of p -values to about 10 −6 , the SCEPTRE p -values for the positive controls were highly significant, and in particular, almost always more significant than the original empirical p -values, indicating greater sensitivity.

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