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Reproducibility of malaria sporozoite challenge model in humans for evaluating efficacy of vaccines and drugs: a systematic review.

BMC Infect Dis · 2021 · PMC8686662 · PMID 34930178

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a decreasing trendno p-value reported
Although infectivity exhibited a decreasing trend in some studies, the data collectively indicate very good performance of the CHMI experiments.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.