MicroRNA-513c-5p is involved in the pathogenesis of preeclampsia by regulating of low-density lipoprotein receptor-associated protein 6.

Our data revealed that 6 miRNAs (hsa-miR-371a-5p, hsa-miR-513c-5p, hsa-miR-126-3p, hsa-miR-145-5p, hsa-miR-193b-5p and hsa-miR-296-5p) were upregulated and showed a trend toward significance in association with PE (Fig. 1 a, miR-371a: P < 0.05, 1.210 ± 0.714, 2.538 ± 0.853; miR-513c-5p: P < 0.05, 1.292 ± 0.754, 2.474 ± 0.809; miR-126-3p: P < 0.01, 1.204 ± 0.780, 4.915 ± 2.424; miR-145-5p: P < 0.05, 1.116 ± 0.523, 2.060 ± 0.670; miR-193b-5p: P < 0.05, 1.170 ± 0.637; miR-296-5p: P < 0.05, 1.870 ± 0.602).

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