Design, synthesis, characterization and <i>in vitro, in vivo</i> and <i>in silico</i> antimicrobial and antiinflammatory activities of a new series of sulphonamide and carbamate derivatives of a nebivolol intermediate.

Among all, 8d, 8c and 9a at a concentration of 100 μM; 8f, 8g and 9a at a concentration of 200 μM against COX-1 and 8c, 8d and 8g at 100 μM; 8d, 8g and 9a at 200 μM against COX-2 exhibited higher content of inhibition akin to the rest of the compounds and the inhibition was highly significant when compared to the celecoxib respectively ( Table 4 ).

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