Resolving Chemical Dynamics in Biological Energy Conversion: Long-Range Proton-Coupled Electron Transfer in Respiratory Complex I.

3 , 40 In addition to the physicochemical importance, the enzyme is also biomedically highly significant as nearly half of all human mitochondrial disorders are linked to point mutations in Complex I. 38 Remarkably, homologues of Complex I, such as the “photosynthetic Complex I” variant, enable cyanobacteria to concentrate CO 2 , most likely driven by the same redox-driven proton pumping machinery as in the canonical variant. 68 However, despite several resolved structures and biophysical experiments, the long-range PCET mechanism and its energy transduction principles still remain unclear.

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