Barely Significant
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Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA.

Cells · 2021 · PMC8699119 · PMID 34943861

Europe PMCDOI
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hedged sentence
0.0600
closest p · 1.2× alpha
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boldest claim

The sentences

a statistical trendp = 0.06so close (0.05 < p ≤ 0.1)
highly significantp = 0.06so close (0.05 < p ≤ 0.1)
In addition, the mouse proteome profiles identified the ClpP-dependent accumulation of GRSF1 as prominent (in ClpP-null MEFs, 4.6-fold and highly significant; in ClpP-null brain pellets, 2.1-fold with actual significance; in ClpP-null brain supernatants, 1.8-fold with a statistical trend p = 0.06; in human fibroblasts, it was detected only in two out of seven controls and was therefore ignored by the filtering algorithm, but imputation revealed a >5-fold highly significant accumulation).

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