a trend toward significancep = 0.108
Indeed, the bootstrapped unstandardized indirect effect (i.e., the effect of TW-Lambda on 30-day mortality going through the considered mediators) was tested to be significant only when considering LVEF as a mediator (estimate 0.235 95% CI 0.113, 0.350, <0.001), though a trend toward significance was also found when considering PVF as the mediator (estimate 0.063, 95% CI −0.013, 0.140, p = 0.108). 4.