Thyroid Hormone Nuclear Receptor TRα1 and Canonical WNT Pathway Cross-Regulation in Normal Intestine and Cancer.

Front Endocrinol (Lausanne) · 2021 · PMC8705541 · PMID 34956074

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highly significantno p-value reported

We also demonstrated in cohorts of CRC patients a significant up-regulation of TRα1 and a positive highly significant correlation between TRα1 expression and WNT pathway activity, therefore validating the relevance of the fundamental observations in clinics ( 16 ).

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