Has Clinical and Epidemiological Varicella Burden Changed over Time in Children? Overview on Hospitalizations, Comorbidities and Costs from 2010 to 2017 in Italy.

A decreasing trend was observed from 2015 to 2017 in children aged 0–3 years old and from 2014 to 2017 in the other age groups.

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The annual incidence rate of cases showed an increasing trend between 2010 and 2012, reached a peak in 2013, with an incidence of 218.58 per 100,000 inhabitants, and from 2015 it declined, reaching 127.46 per 100,000 population in 2017 ( Figure 1 ), in particular according to the upward trend of vaccine coverages at 24 months of age for single antigen that reached values of 10.57% in 2015 (birth cohort 2013), 48.74% in 2016 (birth cohort 2014), 67.89% in 2017 (birth cohort 2015) ( Figure 2 ).

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