Transcriptome-Wide Analysis of Human Liver Reveals Age-Related Differences in the Expression of Select Functional Gene Clusters and Evidence for a PPP1R10-Governed 'Aging Cascade'.

Evidence for a Genetically Governed ‘Aging Cascade’: A Testable Hypothesis Based on the role of the liver as an organ of major systemic relevance; highly significant age-related differences in the expression of PPP1R10 , IGFALS , and DUSP1 ; and ample evidence on the action of their protein products on central aging-associated downstream processes, we now present a broadly substantiated hypothesis on a PPP1R10/IGFALS/DUSP1 -governed ‘aging cascade’.

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