In addition, highly significant increases in chromatin accessibility at loci, such as alpha-T-catenin (Ctnn3) and polycomb group ring finger 5 (Pcgf5), further suggest that VPA exposure leads to changes in chromatin structure at specific key regulatory factors of cardiac and neuronal differentiation programs [ 43 , 44 ].
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Changes in chromatin accessibility landscape and histone H3 core acetylation during valproic acid-induced differentiation of embryonic stem cells.
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