Improvements in the Tolerability Profile of 2'-<i>O</i>-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods.

At the individual sequence level, including mipomersen, the ISR incidence exhibited a decreasing trend in 6 of 13 compounds, and no trend in 7 of 13 compounds with increasing dose number.

also in 47,180 other papers

The incidence of moderate and severe ISR events also exhibited a decreasing trend in 3 of 13 compounds, an increasing trend in 1 compound, and no trend in 9 of 13 compounds with increasing dose number ( Supplementary Fig.

also in 63,971 other papers