Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways.

For example, we obtained highly significant NES for the E2F TARGET and the IL2 STAT5 SIGNALING HALLMARK gene sets for (i) the transcriptome of T-PLL as compared to the one of healthy controls ( E2F TARGETS : NES=1.92, q=0.02; IL2 STAT5 SIGNALING : NES=-2.86, q<0.0001, Online Supplementary Table S6 ) and (ii) for most of the miR differentially expressed in T-PLL ( Figure 3A ).

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