Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma.

1d–g ), transcriptome profiling of two EwS cell lines after either knockdown of EWSR1-ETS or re-expression of TCF7L1 showed a highly significant ( P = 2.57 × 10 − 165 or P = 5.34 × 10 − 272 ) overlap of concordant DEGs (Supplementary Fig. 1e ).

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