Diagnostic Accuracy and Prognostic Relevance of Immunoglobulin Heavy Chain Rearrangement and 18F-FDG-PET/CT Compared With Unilateral Bone Marrow Trephination for Detecting Bone Marrow Involvement in Patients With Diffuse Large B-Cell Lymphoma.

J Korean Med Sci · 2022 · PMC8723897 · PMID 34981678

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3 4 The extent of lymphoma cell infiltration in the BM is a highly significant negative prognostic factor. 5 However, BM trephination biopsy has some limitations of, namely, low sensitivity to patchy or focal BM involvement, inter-observers’ flexibility, and technical problems such as inappropriately obtained specimens. 6 Recent studies demonstrated that 18 F-FDG positron emi

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