Systemic corticosteroids for management of COVID-19: Saving lives or causing harm?

65 , 66 The timing of corticosteroid initiation and the dose may be significant because an observational study of 83 hospitalized patients showed that early use of corticosteroids within 72 h of influenza-like illness onset (17 patients) was associated with increased risk of subsequent critical disease or death and for every 10 mg increase in corticosteroids, the OR was 1.3 (9

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The primary outcome of treatment failure at day 21, defined as death or persistent dependency on high-flow oxygen therapy or mechanical ventilation, was not significantly different between the groups (difference −8.6%; 95% CI, −24.9 to 7.7), although there was a nonsignificant trend in favor of hydrocortisone.

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