The misuse of distributional assumptions in functional class scoring gene-set and pathway analysis.

G3 (Bethesda) · 2022 · PMC8728032 · PMID 34791175

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may not be significantno p-value reported

The advantages of FCSs are the inclusion of genes that may not be significant at the single gene level, the incorporation of the dependence among genes, and the potential to compare contributions of different pathways.

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